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28. Effect of Thyroxine Replacement on Sertoli Cell Function in Men With Hypothyroidism

Aisha Rabel1, Irfan Siddiqui2 and Fatima Abid1

ABSTRACT

Objective: The main objective of the study is to analyse the effect of thyroxine replacement on sertoli cell function in men with hypothyroidism.

Study Design: Descriptive study

Place and Duration of Study: This study was conducted at the Jinnah Postgraduate Medical Center Karachi During January2019 till June 2019.

Materials and Methods: The data was collected from 40 male patients. Those participants who were not willing were not included in this study. Venous blood sample was collected for the analysis of baseline characters. The blood was drawn for the estimation of thyroid levels, FSH, LH, prolactin and testosterone.

Results: The data was collected from 50 patients. The mean age was 25.67±5.67 years. According to our analysis the total motile sperm at baseline was 29% and 80% at follow up. But total progressive motile sperms was 18% at baseline and 45% at follow up. The levels of FSH at baseline was 6.45mIU/mL and after follow up was 6.46 mIU/mL.

Conclusion: It is concluded that sertoli cell function is effected through hypothyroidism and sperm motility is also effected. We can say that hypothyroidism directly effect on the gonads function and sperms motality.

Key Words: Thyroxine, Sertoli Cell, Hypothyroidism

Citation of article: Rabel A, Siddiqui I, Abid F. Effect of Thyroxine Replacement on Sertoli Cell Function in Men With Hypothyroidism. Med Forum 2021;32(3):118-120.