27. Relationship of Platelet- Lymphocyte Ratio with Severity of Obstructive Sleep Apnea Syndrome
Rafia Komal Masood, Muhammad Shoaib and Sadia Falak
Objective: To assess the inflammation in obstructive sleep apnea syndrome patients by using platelet lymphocyte ratio and relationship between platelet lymphocyte ratio and severity of obstructive sleep apnea. Study Design: Retrospective cohort study
Place and Duration of Study: This study was conducted at the Medicine department of Nishtar Hospital Multan from June 2016 to March 2017.
Materials and Methods: Total 280 patients were selected by non-probabilityconsecutive sampling. All patients underwent whole night polysomnography. Patients were divided into control group (AHI <5), mild OSAS group (AHI 5-15), moderate OSASgroup (AHI 15-30) and sever OSAS group (AHI >30) according to their AHI score. Numerical variables like age, body mass index, white cell count, platelets, hemoglobin (Hb) and platelet lymphocyte ratio were statistically analyzed by mean and standard deviation and t-test applied to assess their significance. Qualitative variables like gender and smoking status were statistically analyzed by frequency and percentage. Chi square test was applied to check the significance. P value <0.05 was regarded as significant.
Results: Platelet lymphocyte ratio was significantly raised in patients with obstructive sleep apnea syndrome. There was significant correlation between platelet lymphocyte ratio and AHI (p<0.05). So study showed that there was significant association between obstructive sleep apnea syndrome severity (represented by AHI) and systemic inflammation (represented by PLR). Significant differences were found between age (p=0.000), ESR (p=0.000), CRP (p=0.003), Cholesterol (p=0.000), Platelets (p=0.048), Hb (p=0.000), PLR (p=0.000) and white blood cells (p=0.000), in groups. Association was found between gender (p=0.000) and smoking status (p=0.030) in groups. So, gender and smoking were the effect modifiers.
Conclusion: New inflammatory markers are required to investigate the level of systemic inflammation in obstructive sleep apnea syndrome patients. Platelet lymphocyte ratio, an easy, quick and cheap measurable marker on routine CBC analysis, could be considered for assessing the inflammation in patients of obstructive sleep apnea syndrome.
Key Words: Obstructive sleep apnea syndrome, Platelet lymphocyte ratio, polysomnography
Citation of article: Masood RK, Shoaib M, Falak S. Relationship of Platelet-Lymphocyte Ratio with Severity of Obstructive Sleep Apnea Syndrome. Med Forum 2017;28(11):110-114.