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  3. 24. Comparison of Efficacy of Oral Ibuprofen and Oral Indomethacin in the Treatment of Patent Ductusarteriosus in Premature Neonates
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24. Comparison of Efficacy of Oral Ibuprofen and Oral Indomethacin in the Treatment of Patent Ductusarteriosus in Premature Neonates

Bibi Asma1, Mohammad Shafiq4, Sara Gul2, Faiza Akram5, Sajjad ur Rehman6 and
Asma Khan3

ABSTRACT

Objective: To compare the efficacy of oral ibuprofen and oral indomethacin in the treatment of patent ductusarteriosus in premature neonates.

Study Design: Comparative study

Place and Duration of Study: This study was conducted at the Neonatal care unit Bacha Khan Medical Complex Shah Mansoor Swabi from April 2018 to March 2020.

Materials and Methods: Through non-probability consecutive sampling technique, 120 premature neonates with patent ductusarteriosus (diagnosed as per criteria mentioned in operational definitions) were enrolled for this study and divided into two groups A & B, each with sample size 60. Group A was given oral ibuprofen (10 mg/kg stat followed by 2 doses of 5 mg/kg at 24 hours interval) and group B was given oral indomethacin (0.2mg /kg for 3 doses at 24 hours interval). Chi-square test was used to compare the efficacy between ibuprofen and indomethacin (in term of complete closure of PDA). The informed written consent was taken from parents of each patient. The permission of Ethical Committee was taken before collecting of data and gets publishing in Medical Journal. The finding of data was analyzed for results by SPSS version 20.

Results: In our study, there were 60 patients in each group. The mean age of patients in group A and group B were 8.45 days ±4.827 SD and 8.57 days ±4.996 SD respectively. The male to female ratio in group A &B was 1:1.14 and 1:1.40 respectively. The efficacy of PDA closure in group A was 78.3% (47/60) and in group B was 73.3% (44/60) with a p- value of 0.522 which was statistically not significant.

Conclusion: In our study, oral ibuprofen is as effective as oral indomethacin in the treatment of PDA in premature neonates and is thus an easily available and cost effective alternative to indomethacin in treatment of PDA in premature neonates.

Key Words: Patent ductusarteriosus (PDA), premature neonates, ibuprofen, indomethacin

Citation of article: Asma B, Shafiq M, Gul S, Akram F, Rehman S, Khan A. Comparison of Efficacy of Oral Ibuprofen and Oral Indomethacin in the Treatment of Patent Ductusarteriosus in Premature Neonates. Med Forum 2021;32(6):96-99.