Search Submit Your Manuscript

Become A Member

  1. Home
  2. Novemeber 2017
  3. 23. Comparative Efficacy of Diclofenac Sodium Alone and in Combination with Thiocolchicoside in Patients with Low Back Pain
Article Image
Admin

23. Comparative Efficacy of Diclofenac Sodium Alone and in Combination with Thiocolchicoside in Patients with Low Back Pain

Nauman Akhter and Muhammad Zahid Siddiq

 

ABSTRACT

 

Objective: This study was conducted to determine that combination of a Diclofenac sodium (NSAID) and thiocolchicoside is more effective than Diclofenac Sodium alone or not. Study Design: Observational / prospective study

 

Place and Duration of Study: This study was conducted at the Orthopedics Out-Patient Department, Aziz Bhatti Shaheed Hospital, Gujrat from August 2016 to August 2017.

 

Materials and Methods: Adult patients with acute and sub-acute low back pain was recruited for study and was randomized in group A and group B. A sample of 288 patients, 144 patients in each treatment group was collected by purposive sampling technique.

 

Results: Group A received Diclofenac sodium 75mg two times a day for 7 days and group B received Diclofenac sodium 75mg twice daily plus Thiocolchicoside 4mg twice daily for 7 days. On the day 0 then on the day 3 and day 7, the patients were evaluated for low back pain with a visual analogue scale (VAS) and second outcome measured was hand to floor distance. Descriptive techniques with mean, standard error of mean and graphs were used whereas for inferential statistics, repeated measure ANOVA was used to compare results of day 0, day 3 and day 7. The mean VAS and head to floor distance was equivalent at inclusion. At day 7 pain scores and hand to foot distance was decreased in both groups compared to on day 0 at inclusion. But patients group B receiving combination therapy of NSAID and Thiocolchicoside had significantly less pain and head to floor distance (disability) than group A.

 

Conclusion: Combination of thiocolchicoside and Diclofenac sodium was proved to be more effective than Diclofenac sodium alone for the symptomatic treatment of low back pain, and the combinations was also well tolerated.

Key Words: Diclofenac Sodium, Thiocolchicoside, Muscle Relaxant, Low Back Pain

 

Citation of article: Akhter N, Siddiq MZ. Comparative Efficacy of Diclofenac Sodium Alone and in Combination with Thiocolchicoside in Patients with Low Back Pain. Med Forum 2017;28(11):93-96.