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19. Tumor Necrosis Factor Alpha, Obesity and Polycystic Ovarian Syndrome

Imrana Ihsan, Asma Tehreem Kazi and Shafia Rasool Qazi


Objective: To determine the level of tumor necrosis factor alpha in polycystic ovarian syndrome and to find out correlation of TNF- α with BMI in obese and non-obese females.

Study Design: Cross sectional study

Place and Duration of Study: This study was conducted at the outpatient Department of Lady Aitcheson Hospital Lahore 1st July 2016 to 31st December 2016.

Materials and Methods: Eighty female patients diagnosed with PCOS were selected. Their height in meters (m) and weight in kg was determined and they were divided into cases with BMI> 25kg/m2 and controls with BMI<25kg/m2. 5ml of blood was taken from antecubital vein to measure serum TNF-alpha by ELISA kit.

Results: The mean age of cases and controls was 25.42±4.16 years and 22.98±3.35 years, with significantly lower mean age in controls, p-value < 0.001. The mean BMI was 27.59±5.72 kg/m2 in cases and 22.74±4.44 kg/m2 in controls with significantly higher mean BMI in cases, p-value < 0.001. Mean TNF-α was statistically higher in cases (66.14±122.37 pg/ml) when compared to controls (19.98±37.10 pg/ml), p-value < 0.05.

Conclusion: Serum TNF-alpha was increased in females with PCOS in both cases and controls but levels are significantly higher in cases. No significant correlation was found between TNF-alpha and BMI in either cases and controls. TNF- α level can be used as a molecular marker of disease.

Key Words: Tumor necrosis factor alpha (TNF-α), Body mass index (BM)I, Polycystic Ovarian syndrome (PCOS)

Citation of articles: Ihsan I, Kazi AT, Qazi SR. Tumor Necrosis Factor Alpha, Obesity and Polycystic Ovarian Syndrome. Med Forum 2018;29(4):78-82.