16. Comparative Efficacy of Trimetazidine and Ranolazine in Patients with Angina
Khalil-ur-Rehman, Muhammad Amer Saeed, Tayyaba Gull, and Muhammad Jahanzeb Khalil
ABSTRACT
Objective: To determine the relative efficacy of two newly available metabolically active drugs Trimetazidine and Ranolazine in a subset of patients whose angina symptoms were not ameliorated with optimum dose of conventional anti-anginal medications (B-Blockers, Calcium Channel Blockers and Nitrates), as further increment in their dosage was detrimental for the rate pressure product.
Study Design: Prospective / Descriptive / cross sectional study
Place and Duration of Study: This study was conducted at the Cardiology Department, DHQ Teaching Hospital Dera Ghazi Khan from November 2016 to December 2016.
Materials and Methods: A total of 106 patients with symptomatic angina from Dera Ghazi Khan urban area were divided into two equal groups each consisting of 53 patients. In group 1 Trimetazidine and in group II Ranolazine was added in addition to their routine optimum treatment. They were evaluated after six weeks through a questionnaire for angina symptoms.
Results: The relief of anginal symptoms was 39.6% in group 1 (Trimetazidine grou ) while it was 67.9% in group II (Ranolazine group).
Conclusion: The Ranolazine is more effective in controlling the angina sympt ms as compared to Trimetazidine as early as six weeks.
Key Words: Chronic Angina, Trimetazidine, Ranolazine
Citation of articles: Rehman K, Saeed MA, Gull T, Khalil MJ. omparative Efficacy of Trimetazidine and Ranolazine in Patients with Angina. Med Forum 2017;28(8):59 -62.