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15. Effect of Metformin on Lipid Level in Patients Presenting with Metabolic Syndrome

Qaisar Farooq1, Muhammad Uthman2, Amna Malik3 and Farhan Fateh Jang4

ABSTRACT

Objective: To compare the mean lipid level with metformin versus control in patients presenting with metabolic syndrome.

Study Design: Randomized Control Trial Study

Place and Duration of Study: This study was conducted at the Department of Medicine, Shaikh Zayed Hospital, Lahore, from July, 2019 to January, 2020.

Methodology: After meeting the inclusion criteria 110 patients were enrolled. Informed consent and demographic information was taken. Then blood sample were sent to the laboratory of the hospital for assessment of lipid level including total cholesterol and triglycerides. Patients were randomly divided in 02 groups by using lottery method. In group A, patients were advised to take 1000 mg metformin twice daily for 3 months. In group B, patients were advised diet plan and patients were followed-up in out-patient department for 3 months. After 3 months, blood sample reports were assessed and levels were noted.

Results: The average age of the patients was 49.35±11.44 years, 69(62.73%). On post evaluation, in metformin group the average HDL of the patients was 43.26±6.64mg/dl while in control group the average HDL of the patients was 36.70±3.78mg/dl (p=<0.001) and decrease triglyceride level in metformin groups was noted on follow up.

Conclusion: Metformin is very useful and tolerable drug for the management of patients presenting with metabolic syndrome.

Keywords: Metformin, Metabolic Syndrome, Lipid Profile, HDL, Triglyceride

Citation of article: Farooq Q, Uthman M, Malik A, Jang FF. Effect of Metformin On Lipid Level in Patients Presenting with Metabolic Syndrome. Med Forum 2021;32(5):61-65.