Become A Member

  1. Home
  2. February 2018
  3. 14. Association of Total Red Blood Cell Count with Hemoglobin A2 Level in Beta Thalassemia Trait
Article Image
Admin

14. Association of Total Red Blood Cell Count with Hemoglobin A2 Level in Beta Thalassemia Trait

Shahtaj Khan1, Awal Mir2, Baber Rehman Khattak1 and Tahir Jamal2

ABSTRACT

Objective: To evaluate the association of Red blood cells count with Hemoglobin A2 level in Thalassemia trait individuals. 

Study Design: Descriptive / Observational / cross sectional study. 

Place and Duration of Study: This study was conducted at the Diagnostic Laboratory, Rehman Medical Institute, Peshawar from April 2017 to October 2017.

Materials and Methods: A total of 200 beta Thalassemia trait and 100 normal healthy individuals as a control group were taken in the study.  2ml of blood was collected in EDTA tube and performed CBC and HbA2 from all subjects. All the data collected was recorded and analyzed in SPSS-22. Person correlation was used to find out association between the variables. 

Results: We analyzed a total number of 200 thalassemia trait individuals and among them 116 (58%) were male and 84 (42%) were female participants. The study population age ranges from 1 year to 81 years with median age of 16 years. Highly significant correlation was found between RBC count and HbA2 level with P- value of 0.001. These finding reveals that increase RBC count is directly proportional to the Hb A2 level.    

Conclusion: From the present study it is concluded that hemoglobin A2 level in Thalassemia trait individuals is highly associated with Red blood cell count. Moreover this study confirms that raised RBC count in contrast to Hb with low MCV, MCH and normal MCHC is indication for proceeding with Hb study for diagnosis and counseling them to prevent the birth of beta Thalassemia major children.

Key Words: Beta Thalassemia Trait, Hemoglobin A2 level, RBC count

Citation of articles: Khan S, Mir A, Khattak BR, Jamal T. Association of Total Red Blood Cell Count with Hemoglobin A2 Level in Beta Thalassemia Trait. Med Forum 2018;29(2):57-59.