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  3. 12. Efficacy of Sofosbuvir and Ribavirin for Treatment of Chronic Hepatitis C Genotype 3 Treatment Naïve Non-Cirrhotic Patients at KGN Teaching Hospital Bannu
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12. Efficacy of Sofosbuvir and Ribavirin for Treatment of Chronic Hepatitis C Genotype 3 Treatment Naïve Non-Cirrhotic Patients at KGN Teaching Hospital Bannu

Mohammad Omar Khan1, Abdul Razaq2, Naseeb Rehman4 and
Wasim Ahmad4

ABSTRACT

Objective: to assess the efficacy of oral sofosbuvir and weight-based ribavirin treatmentin non-cirrhotic treatment-naïve patients in district Bannu, Pakistan.

Study Design: A quasi-experimental study

Place and Duration of Study: This study was conducted at the Khalifa Gul Nawaz Teaching hospital (KGNTH) Bannu from June 2016 to January 2018.

Materials and Methods: 340 patients having GT 3 which were non-cirrhotic and treatment naïve. Non-probability consecutive sampling technique was used for sample collection. Treatment was given to all subjects with sofosbuvir (400mg)OD with weight-based ribavirin BD for a period of 24 weeks. PCR was done for follow up at the end of treatment (ETR) and at completion of week 12 of treatment in order to determine virologic response (SVR).

Results: 96.25% (n=318) of the patients had achieved negative PCR at the end of treatment. SVR 12 was achieved in 92.78% (n=306) of subjects in which 84.00% (n=260) had negative PCR. 35.55% (n=117) had Hemoglobin reductions below 10.0g/dl during the treatment course. Females population was found with a sustained virologic response a little more (p=0.003).

Conclusion: Sofosbuvir and RBV based regimen is an effective treatment option for patients in treatment naïve non-cirrhotic GT3 patients with good tolerability and fewer side effects as compared to previous interferon-based regimens.Our results suggest the feasibility and the pertinence if including interferon-free treatment regimens in the national programme, at both provincial and national levels.

Key Words: HCV, Sofosbuvir, Genotype 3, PCR, Hepatitis C,Ribavirin

Citation of articles: Khan MO, Razaq A, Rehman N, Ahmad W. Efficacy of Sofosbuvir and Ribavirin for Treatment of Chronic Hepatitis C Genotype 3 Treatment Naïve Non-Cirrhotic Patients at KGN Teaching Hospital Bannu. Med Forum 2018;29(10):46-50.