ABSTRACT

Objective: To determine with any certainty the association of glycemic control (HbA1c) and high sensitivity C- reactive protein (hs-CRP) in diabetes. Therefore, the present study was carried out to ascertain the relation of glycemic control with hs-CRP levels.

Study Design: Prospective /Longitudinal study

Place and Duration of Study: This study was conducted at the Endocrinology Unit of Hayatabad Medical complex

(HMC). Laboratory analyses was done in the laboratories of Rehman Medical Institute (RMI), Peshawar from April 2015 to October 2015.

Materials and Methods: This longitudinal study was conducted on 125 patients who were known type 2 diabetics visiting Endocrinology unit of HMC. A detailed medical history and clinical examination was carried out to exclude co morbidities. At all three visits i.e baseline, first and second follow up HbA1c and hs-CRP were recorded. Statistical analysis of the data was done by spss version 20 using Pearson correlation test to correlate HbA1c levels with hs-CRP levels.

Results: The mean levels of HbA1c reduced from baseline (9.64±2.25%) to (8.56±1.99%) till second follow up. The correlation between hs-CRP and HbA1c was positive in baseline (r=0.207, p=0.020), the strength of correlation improved in first follow up (r=0.331, p=0.003), in the second follow up the correlation was again positive (r=0.232, p=0.124). The correlation of change in hs-CRP and HbA1c was also positive in all the three data.

Conclusion: The study concluded that there is a significant positive correlation between hs-CRP and HbA1c. Key Words: HbA1c, glycemic control, , hs-CRP, Type 2 diabetes mellitus

Citation of articles: Zulfania, Rehman S, Gaffar T, Durrani M. Effect of Glycemic Control on High Sensitivity C-Reactive Protein Level in Type 2 Diabetes Mellitus. Med Forum 2018;29(3):40-43.

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